- Novel antibody-based cancer immunotherapies to be developed through combining Revitope's dual-antigen precision T-cell engager platform (TEAC) and Junshi Biosciences' antibodies
- Revitope to design up to 5 TEAC molecules against tumor targets selected by Junshi Biosciences
- For each TEAC molecule selected, Revitope to receive up to $160M in development and commercialization milestones, plus tiered royalties on net sales
- Junshi commits to making a conditional equity investment of $10M for 9.99% of Revitope Oncology shares on an as-converted basis
Cambridge, MA & Shanghai, China | July 13, 2020 | Revitope Oncology Inc ("Revitope Oncology")., a biotechnology company advancing a new class of precision cancer immunotherapies, its wholly-owned subsidiary Revitope Limited (Revitope Limited, together with Revitope Oncology, "Revitope") and Junshi Biosciences (1877.HK, 688180.SH), a leading innovation‐driven biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies, today announced the companies have entered into a strategic research collaboration. Revitope will leverage its proprietary protein engineering platform together with Junshi's novel antibody components to develop first-in-class dual-antigen targeting cancer therapies. Revitope is granting Junshi a world-wide exclusive license on products arising from the research collaboration and will receive up to $160 million in development and commercialization milestone payments for each T Cell Engaging Antibody Circuit (TEAC) molecule selected by Junshi, plus tired royalties. Junshi also commits to making a direct equity investment in Revitope Oncology in the amount of $10M for 9.99% of total Revitope Oncology shares on an as-converted basis with terms and conditions to be mutually agreed and subject to compliance with all applicable laws.
"By leveraging Revitope's unique two component T-cell immunotherapy platform and our in-house antibody capabilities reaching from discovery to commercialization, dual targeting precision-based novel cancer immunotherapies can be brought into clinical trials in the near future," commented Dr. Sheng YAO, Vice President of Junshi Biosciences. "As an innovation-driven company, we believe the collaboration with Revitope will empower us to generate a new generation of first-in-class immunotherapy compounds designed to improve both safety and clinical efficacy."
Revitope's proprietary T Cell Engaging Antibody Circuit (TEAC) technology platform exploits co-expressed tumor antigens to enable the development of highly specific cancer drugs with improved safety and efficacy over conventional immunotherapeutic approaches. Revitope's unique approach is based on a pair of tumor-targeted antibodies with a shared T-cell engaging domain which act as inactive pro-drugs unless they encounter cancer cells co-expressing both antigens.
"We are excited to partner with Junshi, a company with state-of-the-art antibody discovery technologies and world-class development capabilities, to advance our unique two-component T-cell engager therapies that have the ability to target tumor cells and deliver more efficacious and safer drugs to patients," said Steve Arkinstall, PhD, CEO, Revitope Oncology.
Under the terms of the Collaboration and License Agreement, Junshi and Revitope will identify development candidate TEAC pairs against agreed upon targets. Revitope will leverage its TEAC protein engineering platform to develop up to five novel TEAC pairs using proprietary sequences from Junshi's antibodies with best-in-class pharmacological and therapeutic activity. Junshi will receive a world-wide license to the TEAC pairs and will have sole responsibility for IND enabling studies as well as clinical development, manufacturing and commercialization. Revitope will receive up to $160M in clinical development and commercialization milestone payments for each TEAC molecule selected, plus tiered royalties on net sales.
About Revitope's T-Cell Engaging Antibody Circuit Technology (TEAC): Tumor-specific Immunotherapies
Because tumors typically do not express cell surface proteins unique to the tumor, conventional bispecific antibody therapeutics can generate unwanted and substantial "on-target, off-tumor" toxicity. Revitope's two-component T-cell engaging antibody circuits (TEACs) are designed to permit specific recruitment and activation of T-cells exclusively by tumor cells. Though developed with traditional tumor targeting domains, TEAC therapies split the CD3 paratope (the T-cell recognition domain) into two halves, with one half on one molecule and the other half on the other molecule. This allows for true dual-antigen targeting to a unique tumor-specific address – two inputs coming together to enable one precision targeted output i.e. a true "and" gate safety feature. Only when the two molecules come together through binding to their different tumor targets on the same tumor cell can the two halves of the CD3 binding domain recombine and create a fully functional anti-CD3 domain (a TEAC). Normal cells expressing only one or neither of the targeted antigens will not elicit activation of a TEAC pair thereby avoiding unwanted toxicity in healthy tissues.
Cambridge, MA. | January 8, 2020 | PRNewswire | Revitope Oncology, Inc., a cancer therapeutics company advancing a novel class of tumor-specific bispecific antibody therapies, today announced the appointment of Steve Arkinstall, D.Phil., as Chief Executive Officer. Dr. Arkinstall brings more than 30 years of experience in biopharmaceutical research and development across multiple diseases areas, and is a respected industry leader.
Most recently, Dr. Arkinstall was CEO of Elstar Therapeutics, a venture-backed biotechnology company developing multi-functional antibody-based therapeutics to treat cancer. He previously was Chief Scientific Officer at Kymab, an antibody therapeutics company founded in Cambridge, UK, prior to which he spent 16 years in progressively senior research leadership roles at EMD Serono, and associated entities in Europe and the United States.
"We are thrilled that a leader of Steve's caliber has chosen to join Revitope at this exciting time in the company's evolution," said Andrew Allen, M.D., Ph.D., Chair of the Revitope Oncology Board of Directors. "Under the skilled direction of CSO and acting-CEO Werner Meier, the company has advanced its core T-cell engaging antibody circuit (TEAC) technology to successful in vivo studies. We must now select our first development candidates and advance into IND enabling studies as a prelude to clinical trials. Steve is a superlative, and experienced executive ideally equipped to lead us through these critical phases."
Revitope's TEAC technology consists of tumor-specific antibody circuits designed to focus immune activation to the cancer cell surface while expanding the antigenic targeting space on solid tumors, avoiding healthy tissues and widening the therapeutic index in immune-oncology.
"A key challenge for immunotherapy for solid tumors in particular, has been the absence of antibody-accessible antigens on the surface of tumor cells which are suitably specific to the tumor," said Dr. Arkinstall. "Revitope's "AND" gate technology, applied to antibody therapeutics, is an elegant and unique approach to the problem that offers a powerful solution. I am excited to be joining the team and look forward to driving this therapeutic approach forward to help cancer patients in a compelling new way. There is an abundance of targets to choose from and tremendous opportunity to leverage our technology through both in-house and partnered programs across cancer types."
Concord, MA | July 10, 2018 | PRNewswire—Applied BioMath (www.appliedbiomath.com), the industry-leader in applying mechanistic modeling, simulation, and analysis to de-risk and accelerate drug research and development, today announced a collaboration with Revitope for an in-vitro and human mechanistic PK/PD modeling of Revitope's bispecific T Cell Engaging Antibody Circuits (TEAC) targeting solid tumors. "TEAC are designed to increase tumor specificity and launch an immune activation only when bound to the cancer cell surface. This innovative engineering approach has the potential to unleash potent immune responses that are focused entirely on the tumor," said Werner Meier, CSO and acting CEO of Revitope Oncology. "Our goal in this collaboration is to leverage Applied BioMath's modeling and analyses capabilities to identify TEAC drug properties that drive the potential for a better therapeutic index and ideally more efficacy in immuno-oncology."
Applied BioMath employs a rigorous fit-for-purpose model development process, referred to as Model-Aided Drug Invention (MADI), which aims to quantitatively integrate knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms. Their MADI approach employs proprietary algorithms and software that were designed specifically for mechanistic PK/PD modeling. "Our mechanistic modeling approach allows our collaborators to assess the feasibility of their therapeutic much more quickly than if they were to rely on experiments alone," said Dr. John Burke, PhD, Co-Founder, President, and CEO of Applied BioMath. "They'll be able to quickly answer strategic questions about the ideal properties for their therapeutic concept and help accelerate development in Lead Generation and by prioritizing experiments, thus helping them get into the clinical faster and for less money with potentially a BIC therapeutic, giving themselves a much higher chance of clinical success and maximizing R&D ROI."
Paris, France & Cambridge, US | April 26, 2018 | GLOBE NEWSWIRE—Independent international pharmaceutical company Servier and LabCentral, a well-known launchpad for innovative startups in the United States, have announced that Revitope, a startup specializing in biotechnology, has won the Golden Ticket awarded by Servier as part of its sponsorship of the prestigious American coworking facility. The prize is a year's residency at LabCentral's facilities for a Revitope scientist. Located in Cambridge, LabCentral is at the heart of scientific and technological innovation in the United States.
Servier has been a Gold sponsor of LabCentral for two years. Each year, it can award a Golden Ticket to a startup in the field of healthcare in order to provide support for a research project corresponding to the Group's development strategy.
"Servier is happy to have given this award to Revitope whose innovative technology could enable the therapeutic antibodies developed by the Group to precisely target the cells to be treated in patients with cancer and inflammatory diseases", said Olivier Nosjean, Scientific Director of the Center of Excellence Research and Biopharmacy. "In an open-innovation approach, Servier is committed to supporting promising startups in the field of healthcare, and particularly oncology, one of the company's priority areas of research."
The Golden Ticket award underwrites the cost of a lab bench for a Revitope scientist to reside in LabCentral's open lab for one year. This includes access to all the latest research equipment, shared infrastructure, extensive programming and services offered by LabCentral. The start-up will also benefit from LabCentral's corporate development support (co-working area, business coaching, investor relations).
"A core principle in every aspect of what we do at LabCentral — from the design of our facilities and speaker series to our sponsorship programs and networking events — is a deliberate attempt to encourage interaction and collaboration," said LabCentral Cofounder and President Johannes Fruehauf, M.D., Ph.D. "The Golden Ticket program is a great example. It's enormously gratifying to see our mission come to fruition, with Servier helping to support Revitope's continued work at LabCentral."
Revitope Oncology is developing prodrug platforms that have the potential to unleash potent immune responses that are focused entirely on the tumor. The company's programmable antibody circuits are designed to focus immune activation to the cancer cell surface while expanding the antigenic targeting space on solid tumors to widen the therapeutic index in immune-oncology.
Revitope Chief Scientific Officer Werner Meier, commented, "We are very excited to have been selected by Servier as their Golden Ticket winner for 2017. It is particularly gratifying that an international pharma leader like Servier — laser-focused on bringing innovative therapies to patients across important therapeutic areas including cancer — is recognizing the potential of the Revitope prodrug platforms to widen the therapeutic index for T-cell redirection. The Servier Golden Ticket provides much-appreciated support that helps us to continue to be part of the LabCentral entrepreneur community — a terrific place for young, life sciences companies to grow."
The cooperation agreement with LabCentral is part of Servier's dynamic collaborative partnership strategy which aims to better respond to the challenges of therapeutic innovation by placing its research activities in the most dynamic research ecosystems where creativity, innovation and entrepreneurship are promoted and valued. This new agreement also confirms Servier's commitment to developing its partnership strategy in the United States.